.. _estimators_MBAR: MBAR ==== The :class:`~alchemlyb.estimators.MBAR` estimator is a light wrapper around the reference implementation of MBAR [Shirts2008]_ from :mod:`pymbar` (:class:`pymbar.mbar.MBAR`). As a generalization of BAR, it uses information from all sampled states to generate an estimate for the free energy difference between each state. API Reference ------------- .. autoclass:: alchemlyb.estimators.MBAR :members: :inherited-members: